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Similarly, preclinical studies show that the GLP-1 receptor liraglutide improves glucose and lipid metabolism by lowering blood glucose, serum total cholesterol, triglyceride, and LDL cholesterol levels, reducing hepatic lipid accumulation, increasing macrophage cholesterol efflux, and upregulating ABCA1 expression, which is critical for HDL synthesis, through extracellular signal-regulated kinase 1/2 pathway activation, as demonstrated in db/db mice on a high-fat diet and in HepG2 cells under high-glucose conditions [26]