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Randomized trial evidence: semaglutide, tirzepatide and liraglutide compared Semaglutide has large randomized controlled trial support for chronic weight management and is FDA approved for this indication, with the STEP program providing the bulk of randomized efficacy evidence STEP 1 trial report Tirzepatide demonstrated greater mean percent weight loss than semaglutide in its pivotal SURMOUNT trials and received regulatory approval for chronic weight management after those results were published SURMOUNT-1 report Liraglutide is an older daily injectable option that is also approved for weight management but generally produces smaller mean weight loss and requires daily dosing, which may affect adherence for some patients Saxenda prescribing information Tonum Research page For readers considering oral adjuncts, evidence backed supplements can be part of a broader plan to support metabolic health but are not replacements for prescription GLP-1 or GIP/GLP therapies

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What to Do If You Miss a Dose Missing an occasional injection happens