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10.1001/jamaneurol.2018.1935 [DOI] [PMC free article] [PubMed] [Google Scholar] 4
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Yet, the efficiency of such interventions is, in many cases, limited, and additional, second-line treatments are frequently implemented, that mainly involve the use of metformin, as insulin-sensitizer, with variable efficacy in terms of improvement of reproductive and metabolic alterations
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