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And it’s a history with its share of ignominy: In the mid-1990s, a drug that combined fenfluramine and phentermine, known as fen-phen, exploded in popularity after a single, 121-patient study showed it was effective for weight loss
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Alterations in food intake by opioid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens
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