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Retatrutide's triple-agonist mechanism (GLP-1 + GIP + glucagon) produces diarrhea in approximately 34% of users at 12 mg, compared to roughly 30% for semaglutide at 2.4 mg

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Retatrutide 12mg is best suited for adults dealing with obesity (BMI ≥30) or overweight individuals (BMI ≥27) with at least one weight-related health condition such as type 2 diabetes, hypertension, dyslipidemia, or obstructive sleep apnea