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--- 🔹Side Effects Drowsiness, dizziness, headache Confusion and memory problems Hypotension and bradycardia (in high doses) Respiratory depression (in overdose) Dependence and withdrawal symptoms on long-term use --- 🔹Contraindications Hypersensitivity to barbiturates Severe liver impairment Porphyria (can precipitate attacks) Respiratory disorders (e.g., sleep apnea) --- 🔹Overdose Signs Severe CNS depression Shallow breathing Coma Hypotension Death due to respiratory arrest --- 🔹Antidote / Management of Overdose Supportive care: airway, breathing, and circulation Activated charcoal (if recent ingestion) Alkalinization of urine (to enhance excretion) Hemodialysis (in severe cases) --- 🔹Forensic Importance Phentobarbital is detectable in toxicological screening and is of forensic significance in: Drug overdose deaths Suicide cases Poisoning investigations Euthanasia confirmations To view or add a comment, sign in A first-in-class endocannabinoid reuptake inhibitor just cleared Phase 1 with clean safety and CNS engagement—could this be the next paradigm in anxiety treatment