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GLP-1 weight loss patients typically lose 30 to 80 pounds and often present with mild to moderate skin laxity, while bariatric surgery patients commonly lose 80 to 150-plus pounds with more severe excess skin
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22 However, the fact that the magnitude and speed of hemoglobin A1c reduction with treatment were identified as risk factors for progression suggests it could be another example of the well-established “early worsening” phenomenon first observed in type 1 diabetic patients intensively treated with insulin in the Oslo Study, Kroc Collaborative Study and Diabetes Control and Complications Trial
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