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New triple-acting hybrid peptides show potential as obesity therapies in knock-out mice [297]

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Cloning of the human pancreatic GLP-1R cDNA was also used to demonstrate comparable binding affinity of exendin-4 and exendin (9–39) to human GLP-1R [363], and consolidated the work of Jean-Pierre Raufman and John Eng that identified exendin-4 as a GLP-1 paralog [366] and exendin (9–39) as a GLP-1R antagonist [367]