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Guidelines on hyperglycemic management recommend either GLP-1RAs or SGLT-2is as second-line treatments for patients with T2D on metformin monotherapy (1, 2), or as first-line treatments in patients with T2D at high or very high cardiovascular risk (3)

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However, that meta-analysis included only nine studies (seven RCTs and two cohort studies), did not evaluate the risk of bias of included studies, nor did it report data on kidney outcomes