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Stress management through techniques like meditation or deep breathing may help, as stress can affect digestive function and symptom perception

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In the phase 2 NEJM 2023 trial, the net glycaemic effect of retatrutide was favourable — improvements in fasting glucose and insulin resistance markers were observed — suggesting that the insulin-stimulating effects of GLP-1R and GIPR agonism counterbalanced any glucose-raising tendency from glucagon receptor activation