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The STEP-1 trial that established semaglutide for weight management capped doses at 2.4 mg weekly and produced 14.9% mean body-weight loss over 68 weeks (Wilding et al., 2021)
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But those steps alone may not help some children reach a healthy weight, Shah said, as things like genetics, hormones and changes in the brain, gut and liver can affect appetite and weight regulation
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