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When pharmacies won't use 2.5 mg/ml: Patients titrating to doses above 2.5 mg (the math doesn't work) Patients without access to 3.0 mL syringes if higher doses are planned Standard semaglutide or tirzepatide protocols where 5 mg/ml or 10 mg/ml is the industry norm If you receive a 2.5 mg/ml vial and your prescription calls for dose escalation beyond 2.5 mg, contact the pharmacy before starting