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Semaglutide [1] $49 .99 per week, up to 0.6 mg, $74.99 per week above 0.6 mg Tirzepatide [2] $99 .99 $124.99 per week, above 8.0 mg [1] In the STEP 5 trial, participants for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes, patients taking semaglutide (typically in doses of 2.4 mg once weekly) for weight management lost an average of about 15% of their body weight over 68 weeks