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These medications work by mimicking natural incretin hormones, which slow gastric emptying, enhance insulin secretion, suppress glucagon release, and reduce appetite through central nervous system pathways

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"So it's very challenging," Yacawych says, "to be able to separate these side effects, like nausea, from GLP-1's intended effects, like weight loss." A possible workaround came from a team led by Ernie Blevins of the University of Washington