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When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion – The pancreas releases insulin in response to elevated blood glucose levels, but only when needed (glucose-dependent mechanism) Reduced glucagon release – Glucagon, which raises blood sugar, is suppressed when glucose levels are adequate Delayed gastric emptying – Food moves more slowly from the stomach into the intestines, promoting satiety Appetite regulation – Signals to the brain's appetite centres reduce hunger and food intake Unlike naturally occurring GLP-1, which is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes, pharmaceutical GLP-1 receptor agonists are chemically modified to resist this degradation
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