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tirzepatide, trial data suggest that such differences may relate to differences in background (placebo) rates in the enrolled trial populations, with the relative increase in many side effects being similar for the two agents (Table 2)

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15-24% at diabetes doses), vomiting, diarrhea, constipation, and abdominal discomfort, which may be difficult to distinguish from neurogenic bowel dysfunction in MS patients [11] [3] Fatigue : Reported in clinical trials and potentially additive to MS-related fatigue, one of the most disabling MS symptoms Dizziness : May occur due to blood pressure changes or dehydration, overlapping with MS-related balance and vestibular symptoms Weight loss induced by tirzepatide—while therapeutically beneficial for metabolic health—requires monitoring in MS patients, as unintentional or excessive weight loss could affect mobility, muscle strength, and overall functional status