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GLP-1 receptor agonists mimic the body’s natural incretin hormone, which: Reduces appetite Slows gastric emptying Improves insulin sensitivity Supports glucose regulation Orforglipron activates GLP-1 receptors without being a peptide, allowing oral absorption without complex delivery systems

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Moreover, none of the treatments altered circulating adiponectin levels, and only mice treated with triagonist showed a significant elevation in serum levels of FGF21 (Suppl