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Semaglutide GLP-1 only 2 mg/week ~10–12% 3–5% Semaglutide GLP-1 only 2.4 mg/week ~15% 3% Tirzepatide Dual GIP + GLP-1 15 mg/week ~22.5% 4.9–5.7% Source: SURMOUNT clinical trial programme (tirzepatide)