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Discussion In this study, we have identified how single amino acid substitutions to exendin-4 can dramatically enhance insulin secretion via modulation of GLP-1R binding kinetics, biased signaling, and trafficking

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High cost and insurance restrictions are common, with many plans requiring step therapy, higher BMI, or documented inability to lose weight by other methods before approval.​ Do GLP-1 drugs replace the need for arthritis or autoimmune medications