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Importantly, both Fc-FGF21 S1 and S3 showed better efficacy than Fc-FGF21 (RA) during the whole administration cycle, especially after day 2 when glucose reducing effect was more obvious, suggesting that the enhanced receptor binding affinity can indeed lead to improve in vivo function of FGF21
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The burden of mortality attributable to diabetes: realistic estimates for the year 2000
