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The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]

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Consistent with data from patients who received IFN treatment (59), plasma DPP4 concentrations, liver enzymes, and cytokine levels were reduced after resolution of infection with direct-acting antiviral therapy with or without ribavirin