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The enormous popularity of new weight-loss drugs often eclipses the downsides: the burden of weekly injections, rough gastrointestinal side effects, muscle and bone loss. That is shaping a race among drug manufacturers
In clinical trials, orforglipron produced clinically meaningful weight loss
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Clinical trials show probiotics produce modest weight loss of 0.5-2 kg, while FDA-approved medications like semaglutide and tirzepatide demonstrate 15-21% body weight reduction with robust clinical evidence
