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Pro-inflammatory cytokine TNF-α activates various receptors that induce apoptosis, including TNF receptors (TNFR) 1 and 2 and cluster of differentiation (CD) 95, whereas IL-1β activates IL-1 receptor (IL-1R) which induces signaling pathways leading to inflammation, excitotoxicity, and neurodegeneration (109, 120)
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