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GLP-1 drugs are associated with a 35% higher risk of NAION, an eye condition that can cause sudden vision loss. About 6 to 10 extra cases per 10,000 users over 3 years.
There's a 10- to 15-day window where neither medication is at full strength
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Exendin-4 also promotes the expression of IRS-1 in pancreatic islets 60
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