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In the ATTAIN-1 phase 3, randomized trial, the use of orforglipron, an oral glucagon-like peptide-1 receptor agonist, led to significant mean body-weight reductions in patients with obesity, as compared with placebo. Full
GLP-1RAs may also have a direct impact by reducing the levels of beta-amyloid and tau hyperphosphorylation in Alzheimer’s disease [76]
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