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Try the BMI Calculator → Table of contents What "not working" actually means (and what it doesn't) The six failure modes: a diagnostic framework Failure Mode 1: Inadequate dosing (the dose-response mismatch) Failure Mode 2: Metabolic adaptation (your body's efficiency response) Failure Mode 3: Caloric compensation (the appetite-behavior gap) Failure Mode 4: Injection technique errors Failure Mode 5: Medication degradation Failure Mode 6: True pharmacological resistance The 14-day diagnostic protocol: which failure mode you have What most articles get wrong about GLP-1 plateaus The FormBlends plateau pattern: what we see in compounded tirzepatide continuation data When dose escalation helps vs when it makes things worse The decision tree: stay, adjust, or switch FAQ Sources Footer disclaimers What "not working" actually means (and what it doesn't) Zepbound "not working" has three distinct clinical definitions, and most patient frustration comes from conflating them: Primary non-response: Less than 5% total body weight loss after 16 weeks at maximum tolerated dose