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GLP-1 Side Effects at a Glance Nausea & vomiting Constipation Diarrhea Reflux & sulfur burps Loss of muscle and lean mass Skin, hair, and nail changes Fatigue, depression, and “the blahs” Dehydration Less Common but Serious Side Effects Pancreatitis and pancreatic cancer Gallstones & gallbladder disease Thyroid cancer Acute kidney injury Retinopathy, macular degeneration, and nonarteritic anterior ischemic optic neuropathy (NAION) Sexual side effects rarely make these lists even though they get asked about constantly, and what is available to treat them has changed more since 2024 than the nausea advice has

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Fatty liver disease, a top cause of liver failure today, also strikes 40% of Cree’s non-Hispanic patients and 65% of her Hispanic patients in her clinic at Children’s Hospital Colorado, she said