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Ex-4 exerted neuroprotective effects independent of endothelin receptor in a similar experiment ( Oxidative stress is one of the mechanisms underlying neuronal damage which may be caused by the acute brain ischemia (ABI) ( As a major source of inflammatory cytokines in lesions after AIS, astrocytes play an important role in recruiting peripheral immune cells, activating microglia, aggravating brain injury, and destroying the BBB
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