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Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), risk of pancreatitis, gallbladder disease, and diabetic retinopathy complications

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By tipping the scales in favor of anti-apoptotic signals, CsA helps to mitigate mitochondrial apoptosis, a process that contributes to cell death and tissue damage in DE conditions