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GLP-1–based therapies offer benefits far beyond weight loss. Clinical trials show meaningful reductions in waist circumference, blood pressure, LDL cholesterol, triglycerides, and A1c, along with improvements in HDL cholesterol. Additional benefits include

Diese Betonung hat jedoch die primäre physiologische Rolle von GLP-1 etwas in den Hintergrund gedrängt: die Regulation der postprandialen Glukose , also die Kontrolle des Anstiegs des Blutzuckerspiegels nach der Nahrungsaufnahme

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Mutational analysis showed that removal of these sites disrupts receptor glycosylation and reduces its cell surface expression, severely impairing GLP-1R signaling