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Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

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Tirzepatide was associated with dose-dependent reductions in body weight with a LSM difference of –5.8 kg (–7.8% reduction), –8.5 kg (–11.0% reduction), and –10.7 kg (–13.9% reduction) for 5 mg, 10 mg, 15 mg, of tirzepatide, respectively, compared with –0.5 kg (–0.7% reduction) for dulaglutide

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