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Obesity variants in the GIPR gene are not associated with risk of fracture or bone mineral density

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Elaborating the results, semaglutide and the GLP-1/GLP-1R signaling system play a pivotal role in glucose regulation by enhancing insulin synthesis though the cAMP-dependent PKA/PI3K pathway, inhibition of pancreatic β-cells apoptosis through AMPK and cAMP-activated CREB and proliferation of pancreatic β-cells by regulation of downstream effector molecules like FOXO1