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An exploratory mediation analysis of the effects on kidney outcomes (composite of macroalbuminuria, decreased GFR, renal death) with liraglutide and semaglutide in patients with T2DM in the LEADER and SUSTAIN-6 trials observed that HbA1c mediated 25–26% and SBP 9–22% of kidney effects with a negligible contribution of the other parameters studied, such as body weight [15]
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[PMC free article] [PubMed] [Google Scholar] 161.Schulman J.L., Carleton J.L., Whitney G., Whitehorn J.C
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