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Thus, the dual agonist was shelved, and the two-incretin concept pursued by adding a weekly dose of a novel, high potency GIPR agonist (NNC080–0389) to semaglutide (2.4 mg) in participants with T2D (ClinicalTrials.gov: NCT05144984), while also exploring the action of different molecular forms of longer-action, multimodal GIP-based agonists in preclinical studies