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Secondary endpoints included percent and absolute change in thigh muscle volume as measured by MRI (except for the group of healthy postmenopausal females randomized receive anti-ActA 10 mg/kg alone Q4W for four doses), percent and absolute change in total and regional body composition (lean mass and fat mass) as measured by DXA (except for the group of healthy postmenopausal females randomized receive anti-ActA 10 mg/kg alone Q4W for four doses), pharmacokinetic profiles of the GDF8 and ActA mAbs (assessed via measurement GDF8 mAb and ActA mAb concentrations) in serum over time, changes in serum total GDF8 and total ActA levels over time, and the presence of anti-drug antibodies against the GDF8 mAb or the ActA mAb