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Common strategies include: Prior authorization requirements to confirm medical necessity Body mass index (BMI) thresholds and comorbidity criteria Step therapy programs requiring lower-cost treatments first Participation in lifestyle or weight-management programs Higher formulary tiers with increased employee cost-sharing Some employers also limit prescribing authority to specific provider types or establish lifetime or annual spending caps where permitted under applicable regulations
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The overall direction and magnitudes of average changes associated with GLP‐1 RA initiation compared to metformin initiation, on HbA1c, eGFR, LDL cholesterol, and triglycerides did not change in subgroups of sex, age, CVD, and hypertension (Figure S7)
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