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Control cells received vehicle treatment (0.1% DMSO)
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In CVOTs of liraglutide (15), semaglutide (16), albiglutide (17), and dulaglutide (18), there were significant reductions in the risk of a three-point composite end point of major adverse CV events (MACE) (CV death, nonfatal myocardial infarction [MI], or nonfatal stroke) with GLP-1 receptor agonist therapy (range of reduction in risk across trials of 12–26%) compared with placebo in patients with type 2 diabetes and multiple CVD risk factors or established CVD
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