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In this phase 2b study, individuals were randomized to receive once-weekly subcutaneous injection of 1, 5, 10, or 15 mg of tirzepatide, 1.5 mg of the GLP-1R agonist dulaglutide (active comparator), or placebo for 26 weeks
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By activating GLP-1 receptors, retatrutide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, and reduces appetite
