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Demonstrated metabolic effects of GIP, GLP-1 and GCG agonism as mono,... | Download Scientific Diagram

Since many neurons of laminae II–III are local interneurons 40 , it is likely that a proportion of the GLP-1R input originates from local interneurons

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Akkermansia muciniphila, a beneficial gut microbe, is part of this picture and has shown promising metabolic effects in early human research, though the GLP-1-specific mechanisms come mostly from animal and laboratory studies