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GIP agonism enhances the central incretin and anorectic effects of GLP-1, while reducing the incidence of nausea (Table 2).1,3,5 The effect on the GLP-1 receptor is biased due to the structure of TZP, which leads to reduced recruitment of beta-arrestin-1,42 thereby contributing to greater potency of the biological effect
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Eating until feeling full and rapid eating both increase metabolic risk factors in Japanese men and women
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