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ELIXA 연구, EXSCEL 연구, PIONEER 6 연구에서는 각각 exenatide, 연속방출 exenatide, 경구용 semaglutide군이 위약 대비 심혈관질환 안전성에 대해 비열등함을 보여주었다(Table 1)
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