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These events included nausea [20 percent (5 mg), 22 percent (10 mg), 40 percent (15 mg)], diarrhea [24 percent (5 and 10 mg), 32 percent (15 mg)] and vomiting [8 percent (5 mg), 16 percent (10 mg), 26 percent (15 mg)], which were mild to moderate and generally temporary, most often occurring during the titration period
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