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Key Pharmacokinetic Parameters The table below describes the key pharmacokinetic parameters for DPP-4 inhibitors: Cautions and contraindications Cautions and contraindications for the use of DPP-4 inhibitors are listed below: Adverse effects Other adverse effects include: Increased risk of infection with saxagliptin, alogliptin and vildagliptin Hypersensitivity reactions (including anaphylaxis, angioedema, stevens-johnson syndrome) Sitagliptin: interstitial lung disease, impaired renal function, thrombocytopenia, and acute renal failure

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When patients hit a plateau at the highest dose, Azagury said that the options are to switch to a more potent drug or consider surgery