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Furthermore, the exclusion of patients with CKD and using BMI in the PSM excluded and accounted for other indications for the use of GLP-1 RAs and ensured that their use in our patient population was for glycemic control

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This review examines a broad spectrum of endogenous peptide–receptor systems that regulate metabolism, appetite, bone–muscle–fat crosstalk, neuroendocrine function, immune modulation, and tissue repair, yet lack approved therapeutic analogs