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A 28-day, MAD phase 1 trial shows mean weight loss of 2.1%, 0.3%, 0.9%, 1.1%, 3.2% and 5.3% for placebo and target doses of 2.5 mg, 5 mg, 10 mg, 20 mg, and 40 mg, respectively (65)
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The theoretical advantage of combining both agents is targeting multiple metabolic pathways: berberine enhances cellular insulin sensitivity, while GLP-1 improves beta-cell function and reduces appetite
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