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The imbalance is compounded by chemokines, such as monocyte-chemoattractant protein-1 (MCP-1), which draw immune cells into adipose depots, fueling chronic, low-grade inflammation [53]

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Discrete choice experiments can formalize the trade-offs patients and clinicians routinely make–between expected weight loss, chances of conception, adverse effects, out-of-pocket costs, and the possibility of post-discontinuation regain–so that Evidence-to-Decision processes can incorporate empirically derived weights rather than implicit assumptions