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Patients with comorbidities, such as depression, anxiety, or sedentary behavior, may experience reduced efficacy.[49] Moreover, over half of the lost weight is often regained after discontinuation.[50] Common side effects include gastrointestinal (GI) symptoms such as nausea, vomiting, and diarrhea,[51] while severe outcomes like pancreatitis or thyroid cancer have not shown significant increases.[52] Notably, weight loss does not always equate to improved health