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Due to the high expression profile of GLP-1R in pancreatic β-cells, GLP-1 analogs (such as exendin-4) have been modified by different methods (to prolong half-life, maintain receptor binding affinity and reduce renal drug accumulation) for theranostic purposes and serve as excellent templates for future cardiovascular drug development[178-184]
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For patients paying cash or without insurance coverage for either medication, compounded semaglutide provides an access option that Trulicity cannot match
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