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The Mesolimbic System: Lowering the Reward Volume If the hypothalamus regulates the homeostatic “stomach hunger” that tells you your body needs fuel, you can think of the mesolimbic system as driving your hedonic “brain hunger.” The mesolimbic system includes the ventral tegmental area (VTA) and nucleus accumbens (NAc)

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These medicines work in two main ways: they make you feel full for longer by slowing stomach emptying, and they calm the parts of your brain that trigger cravings for comfort or enjoyment

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