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In adipose tissue along with PPAR-γ and alpha (PPAR-α), PGC-1α participates in BAT activation and by SIRT1 deacetylation regulates mitochondrial biogenesis and enhances mitochondrial fatty acid oxidation [84,85]
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Individuals with pre-existing diabetic retinopathy, long diabetes duration (typically over 10 years), poor prior glycaemic control, and those experiencing rapid HbA1c reductions face the highest risk
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